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Turkish Archives of Otolaryngology 2005; 43(4): 207-214 Abstract |
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Full Text in Turkish [PDF] 461 KB |
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Histopathologic Assessment of Experimental Acute Sinusitis in Rabbit Tavşanda Deneysel Akut Sinüzitin Histopatolojik İncelenmesi A. Bucak*, M. Kuzdere**, B. Çetindağ**, Ş. Baş** |
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| *ENT Clinics, SSK Afyon Hospital, Afyonkarahisar and **Clinics of Otorhinolaryngology, Head and Neck Surgery, SSK Okmeydanı Tarining Hospital, Istanbul, Turkey |
| Key Words |
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| Histopathology, acute sinusitis, rhinogenic method, rabbit |
| Abstract |
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Objectives:
In this study, investigation of the histopathologic and microbiologic
changes in acute sinusitis was aimed and animal model was planned
accordingly. Methods:
This study was conducted by rhinogenic method using Streptococcus
pneumoniae type 14. On one side of the nasal cavities of the twenty New
Zealand rabbits, a foreign body impregnated with serum physiologic and
on the other side a foreign body impregnated with bacteria were placed
and afterwards, the sacrification of 5 animals weekly was planned. Both
histopathologic and microbiologic assessment was applied to the both
side of the nasal and paranasal sinuses to all of the sample animals. Results:
In histopathologic evaluation of the first two weeks, neutrophil
leucocyts, rare lymphocyts and plasma cells were seen on mucosal and
submucosal tissue. However, in the third and fourth weeks, an intensive
increase in lymphocyts and plasma cells was observed. In bacteriologic
investigation apart from Streptococcus
pneumoniae, E. coli, beta-hemolytic streptococcus, Staphylococcus
aureus were identified. Conclusion: Histopathologically generated sinusitis in all of the animals and the histopathological conclusions were consistent with the natural prognosis of the infection and literature information. |
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| Accepted after revision: | August 23, 2005 | ||
| Correspondence: |
Mustafa Kuzdere, MD Selahattin Pınar Sok. Sağlık Apt. No: 6/4 Mecidiyeköy, Istanbul - Türkiye Phone: (0212) 213 93 53, Fax: (0212) 213 91 29 |
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Copyright © 2005-2006 by the Turkish Otolaryngology & Head and Neck Surgery Foundation. |
