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Turkish Archives of Otolaryngology 2005; 43(3): 137-144 Abstract |
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Full Text in English [PDF] 867 KB |
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Ultrastructural Comparison Between Tympanosclerosis and Atherosclerosis Timpanoskeroz ve Ateroskleroz- Ultrastrüktürel Karşılaştırma A. Koç*, C. Üneri** |
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| *Department of Otorhinolaryngology, Head and Neck Surgery, Haseki Training and Research Hospital, and **Medical Faculty of Marmara University, Istanbul, Turkey |
| Key Words |
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| Tympanosclerosis, atherosclerosis, calcification, genetic predisposition |
| Abstract |
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Objectives:
The aim of this study is to identify the shared similar characteristics
of tympanosclerosis and atherosclerosis on light and electron microscopy
and to find out if there is a genetic predisposition between these two
conditions. Methods:
Tympanosclerotic materials were taken from 7 patients who were operated
on due to chronic otitis media and atherosclerotic materials were taken
from 4 patients on whom coronary arterial bypass grafting operations had
been performed. Tympanosclerotic and atherosclerotic specimens were
examined under light and electron microscopy. Results:
In the examination of the specimens, the important common
characteristics in both specimen groups were increase in collagen fibers,
presence of calcified areas, increase of the infectious cells and
especially the fibroblasts. Conclusion: In tympanosclerosis and atherosclerosis, the basic mechanism of the reaction goes through the same routes. Both the ultrastructural similarities between atherosclerosis and tympanosclerosis as well as the sexual difference seen in each of the two diseases, in addition to the incidence of tympanosclerosis observed on atherosclerotic patients in comparison to the normal population, is indicating that the genetic-familial predisposition of sclerotic changes is shared by all tissues, and that tympanosclerosis must be the appearance of the same genetic characteristic in the middle ear. |
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| Accepted after revision: | January 3, 2005 | ||
| Correspondence: |
Ahmet Koç, MD Acıbadem Mah. Tekin Sok. 1/18 Kadıköy 34718 İstanbul - Türkiye Phone: (0216) 651 00 00, Fax: (0216) 651 00 45 e-mail: ahmetkoctr@yahoo.com |
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Copyright © 2005 by the Turkish Otolaryngology & Head and Neck Surgery Foundation. |
