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Turkish Archives of Otolaryngology 2004; 42(3): 140-148 Abstract |
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Full Text in English [PDF] 779 KB |
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Effects
of Thinner Inhalation on the Rat Nasal Mucosa
Sıçanlardaki Tiner
İnhalasyonunun Burun Mukozası Üzerine Etkileri |
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| *Haydarpasa Numune Hospital, Department of Otorhinolaryngology&Head and Neck Surgery, **Marmara University, Faculty of Medicine, Department of Pathology, and ***Haydarpasa Numune Hospital, Department of Gastroenterology, Istanbul, Turkey |
| Key Words |
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| Thinner, nasal mucosa, toxicity |
| Abstract |
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People are exposed to volatile substances by inhalation, skin contact or oral intake, because these are widely used in industry. In recent years these substances are abused for their euphoric effects, especially thinner. Among these substances, thinner is the choice of the young people with low socioeconomic level and familial problems due to the expense, hardness to find and illegality of other drugs. In addition, many more are unwillingly exposed to these substances at work. So it’s becoming more important to find out the effects of thinner inhalation on nasal mucosa. This experimental study was performed to evaluate the effects of thinner on the nasal mucosa. Four groups were dispersed due to inhalation periods. Exposure periods of the first, second, third and fourth groups were 1 week, 3 weeks, 4 weeks and 5 weeks respectively. Thinner inhaled animals lost weight within weeks. Loss of weight in the third group was found to be statistically significant compared to other groups and controls (p<0.05). Central nervous system toxicity was observed in the thinner inhaled groups. Inflammatory response which was most prominent in the first group decreased within weeks. But in comparison with other groups, the difference was statistically not significant (p>0.05). Squamous metaplasia, epithelial stratification and budding were formed by the first week; but no statistically significant increase was detected till the end of the 5th week (p>0.05). Epithelial villous hypertrophy appeared in the second group and became significantly prominent during following weeks in other groups as well (p<0.01). In conclusion, villous formations, budding, stratifications which are different forms of epithelial hyperplasia; and squamous metaplasia were observed in the nasal mucosa which exposed to thinner. So it was shown that thinner is harmful for the nasal mucosa as well as for the other organs of the respiratory system. |
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| Accepted after revision: July 16, 2004 | |||
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Correspondence: |
Sema Zer Toros, MD Department of Otorhinolaryngology&Head and Neck Surgery, Haydarpaşa Numune Hospital Istanbul - Türkiye, Phone: (0216) 414 45 02 / 1745 e-mail: semazertoros@hotmail.com
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Copyright © 2004-2005 by the Turkish Otolaryngology & Head and Neck Surgery Foundation. |
