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Turkish Archives of Otolaryngology 2002; 40(1): 23-27 Abstract |
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The
effect of Budesonide that is the Topical Corticosteroid on the Rat Nasal
Mucosa (Experimental Study)
Topikal Kortikosteroid Olan Budesonidin Rat Nazal Mukozasına Etkisi (Deneysel Çalışma) Atila Güngör*, Ethem Poyrazoğlu*, Şükrü Yıldırım**, Serhat Basutcu***, Hasan Candan* |
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| *GATA Haydarpaşa Training Hospital, ENT Clinic, **Pathology Clinic, İstanbul, and ***İskenderun Military Hospital, ENT Clinic, Hatay, Turkey |
| Key Words |
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| Budesonide, corticosteroid, rat, topical |
| Abstract |
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In this study efficacy of frequently used topical corticosteroids in rhinitis of rat nose was investigated. Topical corticosteroid, budesonide was applied twice a day 10 mL into the noses of 10 rats in study group and serum physiologic was applied into noses of 6 rats in control group for 21 days. Histopathologic findings from three different sites, one from anterior site nearby incisor teeth, one from posterior site around hard palate and one from second tracheal ring were correlated. There were no significant differences regarding edema, ciliary loss and intraepithelial loss. Fibrosis, increase in epithelial thickness at anterior slides, infiltration of inflammatory cells at posterior slides and increase in goblet cells were found significant. Budesonide was found as a safe topical corticosteroid for nasal mucosa. |
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| Accepted: November 20, 2001 | |||
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Correspondence: |
Atila Güngör, MD GATA Haydarpaşa Eğitim Hastanesi KBB Kliniği Üsküdar 81327 İstanbul - Türkiye, Phone: (0216) 346 26 00, Fax: (0216) 348 78 80 e-mail: atilagungor@ixir.com
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Copyright © 2002-2005 by the Turkish Otolaryngology & Head and Neck Surgery Foundation. |
