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Turkish Archives of Otolaryngology 1997; 35(1-2): 33-37 Abstract |
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Full Text in Turkish [PDF] 506 KB |
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Histological
Evaluation of Basic Fibroblast Growth Factor Effect on the Healing of
Traumatic Tympanic Membrane Perforation Travmatik
Timpan Membran Perforasyon İyileşmesinde Basic Fibroblast Growth Faktörün
Etkisinin Histolojik İncelenmesi |
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| *Ankara Numune Hospital, 2nd ENT Clinic, **1st ENT Clinic, ***Pathology Clinic, and ****Ankara University, Medical Faculty, Department of Physiology, Ankara, Turkey |
| Key Wordsü |
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| Basic fibroblast growth factor, tympanic membrane, perforation |
| Abstract |
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Topical application of basic fibroblast growth factor (bFGF) on traumatic tympanic membrane (TM) perforations was studied in 14 guinea pigs. The animals were divided into two equal groups. In the first group, the growth factor was applied directly to the perforation in repeated three doses. Same dose was applied once in the second group. All the left ears were used as control groups. The tympanic membranes were assessed using light microscopy. In the study group, tympanic membranes were more thick and there were hyperplasia of the epithelial layers. There also were hyperplasia of the connective layers in which many fibroblasts and numerous vessels were found. These results demonstrate that bFGF enhance the repairment process of the epithelial and connective tissues. So, the atrophic healed tympanic membrane may be prevented by bFGF. |
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Correspondence: |
Hüseyin
Dere, MD |
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Türk Otolarengoloji Arşivi / Turkish Archives of Otolaryngology |
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Copyright © 2002-2006 by the Turkish Otolaryngology & Head and Neck Surgery Foundation. |
